It appears the game of the week is solely picked by which game has the closest spread. For example, CUST-35 has two winless teams playing each other in the game of the week.
There should probably be some other factors involved. Closest spread, league ranking and division matchup should come into play. Oklahoma City vs Triple Threat is clearly the game of the week when taking all of those factors into consideration. There are some other good games, but this is the only division matchup with a decent point spread (which should be less than it is).
Just my two cents; I have zero idea how hard it would be to incorporate the additional factors.