I haven't seen any reason to crank down the injury frequency. From my anecdotal observation from my own team, it seems injuries are not as frequent or as serious as the actual NFL. I rarely get season ending injuries. I do get the regular multi-week injuries every season, but that's part of real life. Football is a dangerous game!
Hint: you can reduce injuries by changing your fatigue settings. However, the trade off is that your stars are less likely to get injuries because they are sitting on the bench more.